Scientific exploration shows Juices can lower Cholesterol and Prevent Heart Disease.

Heart disease effects lots of us in the UK, more so than in lots other countries, but there is a powerful possibility that this can be changed easily by changing our attitude towards food and consuming more juice.

The phrase �heart disease’ consists of several conditions such from Congenital heart defects seen at birth to atherosclerosis (hardened arteries) that create later. It is a complicated issue with many inter-related circumstances. Hardening of the arteries and angina are a result of the inner walls of the bodies arteries narrowing as a result of a create up of plaque (fat, LDL cholesterol and other substances). Plaque create up is increased in people who have high levels LDL (bad) cholesterol and low levels HDL (good) cholesterol. Oxidation of excess LDL cholesterol results in an expand of plaque. The HDL cholesterol contributes to prevent the LDL cholesterol from going up the plaque, moving it as a substitute to the liver. Plaque create up alone can be enough to cause pain (angina) or heart attack. though, if the plaque is ruptured or torn it can block the artery provoking a coronary thrombosis (heart attack). Atherosclerosis can in addition be a cause of inappropriate platelet activation provoking the platelets in the blood to clot.

Grape Juice inhibits Atherosclerosis

Many of us will have seen news items claiming red wine contributes to keep our hearts healthy. This is as a result of a substance in the grapes that used to commit the wine considered as polyphenols. though, recent tests have shown that despite the fact less polyphenols are present in grape juice than red wine, grape juice is better at inhibiting atherosclerosis [1]. Purple Grape juice has in addition been discovered to help patients with coronary artery disease as a result of significantly improving the function of the cells (endothelial) lining the hardened arteries likewise inhibiting inappropriate platelet activation [2]. Purple grape juice’s action as a strong platelet inhibitor is important as Platelets are involucred in the development of Atherosclerosis [3]. Other exploration has shown grape seed proanthocyanidin extracts reducing Atherosclerosis by up to 50% in animals. [4] despite the fact that study was for grape seed extract alone, other studies have shown that the fusion of grape seed extract and grape skin, as you would find in the juice, is more efficient [5].

Fruit Juices lower Cholesterol

Pomegranate juice in addition offers broad protection contrary cardiovascular diseases6 and has been shown to lower cholesterol create up in plaque [7] and lower the development of atherosclerosis [8].

In laboratory tests orange juice has been discovered to reduce cholesterol and significantly inhibit atherosclerosis [9]. A 750ml serving of orange juice every day has been shown to diminished the LDL-HDL cholesterol ratio by 16% in tests on people [10]. Tests on smokers has shown that carrot and orange juice combined significantly susceptibility of LDL to oxidation [11] (the process that increases plaque).

As small as 330 mL of tomato juice [12] has in addition been shown to significantly lower LDL oxidation [13]

Adding garlic to vegetable juices takes a couple of getting used to, but garlic has in addition been shown to reduce bad LDL cholesterol while expand HDL cholesterol [14] and also reducing LDL oxidation [15].

Plant sterols and stanols discovered in high quantities in veg like broccoli, Brussels sprouts, cauliflower16 have been discovered to lower LDL cholesterol [17]. One report mentions around 2g per day of plant sterol ester can reduce LDL cholesterol levels from 9% to 20% [18]

Ginger has in addition been shown to significantly lower LDL cholesterol and abnormal cell tissues (Aortic atherosclerotic lesion) [19] in the arteries around the heart.

With so much evidence proving the advantages of fruit and vegetable juices why on earth would we not need to include them in our diet?

1 Atherosclerosis. 2001 May;156(1):67-72. Red wine, dealcoholized red wine, and specifically grape juice, inhibit atherosclerosis in a hamster model. Vinson JA, Teufel K, Wu N. Department of Chemistry, University of Scranton, Linden and Monroe Streets,

2 Adv Exp Med Biol. 2002;505:95-111. Potential health profits from the flavonoids in grape products on vascular disease. Folts JD. Coronary Thrombosis exploration Laboratory, University of Wisconsin Medical School, Madison, USA.

3 J Nutr. 2000 Jan;130(1):53-6. Grape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation. Keevil JG, Osman HE, Reed JD, Folts JD. Cardiology Section of Department of treatment, University of Wisconsin, Madison,

WI 53792, USA.

4 ol Cell Biochem. 2002 Nov;240(1-2):99-103. favourable effects of a novel IH636 grape seed proanthocyanidin extract and a niacin-bound chromium in a hamster atherosclerosis model. Vinson JA, Mandarano MA, Shuta DL, Bagchi M, Bagchi D. Department of Chemistry, University of Scranton, Scranton, PA, USA.

5 J Nutr. 2002 Dec;132(12):3592-8. Grape seed and grape skin extracts elicit a larger antiplatelet end result when used in conjunction than when used one by one in dogs and humans. Shanmuganayagam D, Beahm MR, Osman HE, Krueger CG, Reed JD, Folts JD. Department of Cardiovascular treatment, University of Wisconsin, Madison 53792,

USA.

6 Atherosclerosis. 2001 Sep;158(1):195-8. Pomegranate juice consumption inhibits serum angiotensin converting enzyme

activity and decreases systolic blood stress. Aviram M, Dornfeld L. The Lipid exploration Laboratory, Technion Faculty of treatment, The Rappaport Family Institute for exploration in the Medical Sciences, 31096 Haifa, Israel.

7 J Nutr Biochem. 2005 Sep;16(9):570-6. Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages. Fuhrman B, Volkova N, Aviram M. Lipid exploration Laboratory, Technion Faculty of treatment, The Rappaport Family Institute for exploration in the Medical Sciences, Rambam Medical Center, Haifa 31096, Israel.

8 J Nutr. 2001 Aug;131(8):2082-9. Pomegranate juice supplementation to atherosclerotic mice decreases macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis.

Kaplan M, Hayek T, Raz A, Coleman R, Dornfeld L, Vaya J, Aviram M.

The Lipid exploration Laboratory, Bruce Rappaport Faculty of treatment, Technion, The Rappaport Family Institute for exploration in the Medical Sciences and Rambam Medical Center, Haifa 31096, Israel.

9 Adv Exp Med Biol. 2002;505:113-22. Polyphenol antioxidants in citrus juices: in vitro and in vivo studies related to heart disease. Vinson JA, Liang X, Proch J, Hontz BA, Dancel J, Sandone N. Department of Chemistry, University of Scranton, PA 18510-4626, USA.

10 Am J Clin Nutr. 2000 Nov;72(5):1095-100. HDL-cholesterol-raising end result of orange juice in subjects with hypercholesterolemia. Kurowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piche LA, Serratore P. Departments of Biochemistry, University of Western Ontario, London, Canada.

11 Clin Chem. 2000 Nov;46(11):1818-29. Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. Chopra M, O’Neill ME, Keogh N, Wortley G, Southon S, Thurnham DI. Northern Ireland Centre for Diet and Health, School of Biomedical Sciences, University of Ulster, Coleraine, County Londonderry, Northern Ireland BT52 1SA, United Kingdom.

12 J Nutr. 2000 Sep;130(9):2200-6. Moderate intervention with carotenoid-rich vegetable products decreases lipid peroxidation in men. Bub A, Watzl B, Abrahamse L, Delincee H, Adam S, Wever J, Muller H, Rechkemmer G. Institute of Nutritional Physiology, Federal exploration Centre for Nutrition, D-76131 Karlsruhe, Germany.

13 Lipids. 1998 Oct;33(10):981-4. Tomato lycopene and low density lipoprotein oxidation: a human dietary intervention study. Agarwal S, Rao AV. Department of Nutritional Sciences, Faculty of treatment, University of Toronto, Ontario, Canada.

14 J Nutr. 2001 Mar;131(3s):994S-9S. Study of garlic extracts and fractions on cholesterol plasma levels and vascular reactivity in cholesterol-fed rats. Slowing K, Ganado P, Sanz M, Ruiz E, Tejerina T. Department of Pharmacology, School of Pharmacy, Complutense University, 28040 Madrid, Spain.

15 J Nutr. 2001 Mar;131(3s):985S-8S. Suppression of LDL oxidation by garlic. Lau BH. Department of Microbiology and Molecular Genetics, School of treatment, Loma Linda University, Loma Linda, CA 92350, USA.

16 Curr Opin Lipidol. 2000 Dec;11(6):571-6. Therapeutic potential of plant sterols and stanols. Plat J, Kerckhoffs DA, Mensink RP. Department of Human Biology, Maastricht University, Maastricht, the Netherlands.

17 Am J Clin Nutr. 2002 Jan;75(1):79-86. An expand in dietary carotenoids when consuming plant sterols or stanols is

effective in maintaining plasma carotenoid concentrations. Noakes M, Clifton P, Ntanios F, Shrapnel W, Record I, McInerney J. CSIRO Health Sciences and Nutrition, Adelaide, Australia.

18 Circulation. 2001 Feb 27;103(8):1177-9. AHA Science Advisory. Stanol/sterol ester-containing foods and blood cholesterol

levels. A statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical task, and Metabolism of the American Heart Association. Lichtenstein AH, Deckelbaum RJ.

19 J Nutr. 2000 May;130(5):1124-31. Ginger extract consumption decreases plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein

E-deficient mice. Fuhrman B, Rosenblat M, Hayek T, Coleman R, Aviram M. Lipid exploration Laboratory, Technion Faculty of treatment, The Rappaport Family Institute for exploration in the Medical Sciences and Rambam Medical Center, Haifa,

Israel.

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